伊利诺伊大学厄巴纳-香槟分校程建军教授学术报告

报告题目：New synthetic polymeric biomaterials and cancer-targeting technology

报告人：程建军  教授

 Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61821, USA

主持人：陈永明  教授

时间：2017年6月13日（星期二）下午16：00

地点：丰盛堂芙兰学术交流中心A403

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报告人简介：

I will report the integration of ring-opening metathesis polymerization (ROMP) and ring-opening polymerization of the amino acid N-carboxyanhydride (NCA) to allow facile synthesis of brush-like polymers containing polypeptide brush. ROMP of N-trimethylsilyl norbornenes renders the preparation of poly(norbornene)s bearing pendant N-TMS groups. Polypeptide brushes with up to 1000 degree of polymerization can be obtained with low polydispersity. Cooperative polymerization of NCA was found and the polymerization of controlled by the brush polypeptide helices. I will also present sugar molecule mediated in vivo cancer targeting.  We successfully developed azido-sugar derivatives that can label triple negative breast cancer and enable successful in vivo targeting.